Sex Hormone Research Center
The Sex Hormone Research Center (SHRC, 性荷爾蒙研究中心) was established in 2010 with the recruitment of Dr. Chawnshang Chang (張傳祥), who founded it, and is also the current Director. The lab is located in the Cancer Research Building at CMU and has 7 member professors, who serve as the principal investigators. The lab's interest is mainly in sex hormones (particularly androgen), nuclear receptors, and the effects of Vitamin D and E on prostate and bladder cancer and other hormone-related diseases.
The principle programs of the SHRC are based on treating diseases related to androgen receptors (AR) and specific signal transducer and activation of transcription (STAT) activation pathways. Furthermore, the major platform applications include treating androgen-dependent diseases in both topical and systemic treatment settings and novel cancer treatments.
Research Goals
Androgen-androgen receptor (A-AR) molecular mechanisms
To dissect the molecular mechanism of how A-AR functions.
A-AR physiological functions
Mice with knockout AR in specific cells (ARKO mice) have been generated in our lab to study the roles of AR in bone, immunity, and reproductive systems in vivo, as well as in tumors in the liver, prostate, bladder, and breasts.
ER in vivo roles in urology
We established ERαKO and ERβKO mice—that is, mice with knockout ERα or ERβ in specific cells—to study the roles of ER in the prostate, bladder, and testes.
TR4 nuclear receptor
We have investigated the functions of TR4 as a transcription modulator with important in vivo roles in metabolic syndrome, fertility, aging, and cancer.
Vitamin D receptors in urology
To study the functions of Vitamin D in vivo in prostate and bladder cancers.
Vitamin E in urology
To study the function of Vitamin E in vivo in prostate and bladder cancers.